Transthyretin cardiac amyloidosis is a complex condition resulting from the abnormal accumulation of a protein in the heart, progressively impairing its function. It is nicknamed the 'Chameleon Disease' because its initial manifestations can appear years before cardiac symptoms, presenting as seemingly unrelated rheumatological, orthopedic, or auditory issues.
Warning signs to watch for include a combination of history such as carpal tunnel surgery (especially bilateral), spontaneous rupture of a biceps or shoulder tendon, spinal stenosis, Dupuytren's contracture, trigger finger, or progressive hearing loss. The onset of unusual shortness of breath, rapid weight gain, leg edema, or persistent fatigue should also prompt medical consultation.
While these symptoms are not necessarily linked to amyloidosis, their association may warrant further investigation. The screening days are primarily aimed at individuals over 50 with suggestive rheumatological, orthopedic, or auditory history, particularly when combined with cardiac symptoms. A screening questionnaire, called R’EPOF, is used to identify patients who may benefit from a cardiological consultation.
The main objective of this campaign is to reduce diagnostic delays and promote earlier patient management. Supported by various learned societies (cardiology, rheumatology, orthopedics, hand surgery, ENT, geriatrics) and patient associations, it is coordinated by cardiologist Pr Thibaud Damy and rheumatologist Pr Thomas Bardin. Over 50 French hospital centers are involved in this initiative.
All information about the disease and the campaign is available on the website www.maladiecameleon.fr. The initiative calls for collective action: 'Together, let's unmask the Chameleon Disease. Together, let's save lives!'
